Study of Patients’ Characteristics and Mutual Impact Between Covid-19 and Hyperglycemia at a Community Hospital in Central Brooklyn

Background: Studies have shown that poorly-controlled hyperglycemia worsens the outcomes in patients with COVID-19 (C-19) and C-19 may damage pancreatic islets via ACE2 receptors causing acute hyperglycemia The major population we serve at Kingsbrook Jewish Medical Center (KJMC) are underprivileged with many of them having multiple comorbidities Methods: This is a retrospective study wherein patients, admitted from February 2020 to April 2020 with hyperglycemia, were selected and divided into 2 groups based on presence or absence of C-19 Data include demographics, comorbidities, blood glucose level, serum osmolality, serum bicarbonate, anion gap, acute kidney injury (AKI), serum creatinine, ICU admission, length of stay (LOS) and mortality Data were analyzed using descriptive study and T-test Results: 100 patients were included in the C-19 group (CG) and 88 patients were included in the Non C-19 group (NCG) Major comorbidities were similar in both groups including HTN, DM, CKD followed by ESRD Mean age of patients (years) was 65 68 in CG and 61 17 in NCG 61% were male in CG and 53 41% were male in NCG 16% and 9% developed DKA and HHS in CG, and 13 64% and 6 82% developed DKA and HHS in NCG respectively 15% in CG had combined DKA H0 0001) Mean anion gap was 17 93 (SD±7 6) in CG and 13 10 (SD±7 2) in NCG (pl0 0001) 56% in CG and 37% in NCG developed AKI respectively (p=0 01) Mean serum creatinine (mg/dl) was 4 22 in CG and 1 65 in NCG (p=0 004) 55% of CG were admitted to ICU and 34% of NCG were admitted to ICU (p=0 003) Median LOS (days) in discharged patients was 8 in CG and 5 in NCG (p=0 02) Mortality was 40% in CG and 3 41% in NCG (pl0 0001) 12 patients in CG and 2 patients in NCG developed new-onset diabetes In the subset of DKA, interestingly, mean age (years) was 61 63 (SD±17 73) in CG and 39 67 in NCG (SD±13 39) (p=0 001) Conclusion: In our study, patients in the CG carry worse laboratory parameters, unfavorable clinical outcomes and strikingly higher mortality We discovered increased incidence of new-onset diabetes and elderly DKA in CG In an inner city population like ours, the burden of DM with significant social and health care disparities is quite severe Diabetic patients with concurrent C-19 infection can have particularly negative outcomes and C-19 possibly damages the pancreatic islets resulting in acute hyperglycemic crisis Further research on larger population is required References: (1)https://dx doi org/10 1016%2Fj diabres 2020 108142(2) https://doi org/10 2337/dc20-0723(3)https://www nejm org/doi/full/10 1056/NEJMc2018688