Novel isopentene flavone compounds and application thereof

2011 
The invention discloses five types of novel isopentene flavone compounds and application thereof to the preparation of medicaments for treating the mammary cancer. The five types of novel isopentene flavone compounds are novel compounds separated from himalayan mayapple fruit, and refer to 8-isopentene meletin3-methyl ether (1), 3'-isopentene kaempferol3-methyl ether (2), 8-isopentene-2',3'-(3''',3'''-dimethyl pyran)-5,7,4'-trihydroxy-3-methoxyl flavone (3), 7,8-(3'',3''-dimethyl pyran)-2'-isopentene-5,3',4'-trihydroxy-3-methoxyl flavone (4) and 7,8-(2''-isopropenyl furan)-2'-isopentene-5,3',4'-trihydroxy-3-methoxyl flavone (5) respectively. The structures of the five types of novel isopentene flavone compounds are shown as structural formulas 1 to 5. As proved by suppression experiments on human mammary cancer cells, the series of compounds have a good mammary cancer amplification suppressing effect.
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