Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

James J. Li,Haixia Wang,Fucheng Qu,Christa Musial,Joseph A. Tino,Jeffrey A. Robl,Dorothy Slusarchyk,Rajasree Golla,Ramakrishna Seethala,Kenneth E.J. Dickinson,Leah Giupponi,Gary J. Grover,Paul G. Sleph,Neil Flynn,Brian J. Murphy,David A. Gordon,Melissa Kung,Robert H. Stoffel

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

2005

James J. Li
Haixia Wang
Fucheng Qu
Christa Musial
Joseph A. Tino
Jeffrey A. Robl
Dorothy Slusarchyk
Rajasree Golla
Ramakrishna Seethala
Kenneth E.J. Dickinson
Leah Giupponi
Gary J. Grover
Paul G. Sleph
Neil Flynn
Brian J. Murphy
David A. Gordon
Melissa Kung
Robert H. Stoffel

Abstract Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a – E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.

Keywords:

Hormone
Tetrahydroisoquinoline
Chemical synthesis
Organic chemistry
In vivo
In vitro
Bicyclic molecule
Somatotropin-releasing factor
Stereochemistry
Biochemistry
Chemistry
Carbamate
Oligopeptide
tertiary amine

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