Human papillomavirus prevalence in postradiotherapy uterine cervical carcinoma patients: correlation with recurrence of the disease.
2006
Singh RK, Maulik S, Mitra S, Mondal RK, Basu PS, Roychowdhury S, Panda CK. Human papillomavirus
prevalence in postradiotherapy uterine cervical carcinoma patients: correlation with recurrence of
the disease. Int J Gynecol Cancer 2006;16:1048–1054.
To understand the role of human papillomavirus (HPV) in recurrence of uterine cervical cancer (CA-CX)
after radiotherapy, we have analyzed the HPV prevalence in the exfoliated cells of 56 patients and their
corresponding plasma. HPV DNA was detected in exfoliated cells of 78% (44/56) patients (HPV-16, 68%;
HPV-18, 14%; HPV-X [other than 16, 18], 11%; and mixed infection of HPV-16 and HPV-18 in three cases).
HPV DNA in plasma was present in only 25% (11/44) of the HPV-positive exfoliated cells (positive predictive
value, 100%; negative predictive value, 27%) with concordance in HPV types. The recurrence of the
disease was significantly associated with the presence of HPV in the exfoliated cell (P ¼ 0.01) and plasma
(P ¼ 0.007) as well as high viral load in the exfoliated cell (P ¼ 0.0002). Kaplan–Meier disease-free estimates
have also shown the significant association between HPV prevalence in plasma and recurrence of the
disease (P ¼ 0.045). Thus, it indicates that in postradiotherapy CA-CX patients, the high viral load in the
exfoliated cell as well as HPV presence in the plasma samples could be used in early detection of the patients
at increased risk for disease recurrence and progression
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