Risk factors for hepatitis C virus infection in individuals infected with the HIV
2008
Abstract Background Except for injecting drug use, other routes of transmission for hepatitis C virus among HIV–AIDS patients have not been consistently described, and risk estimates are often not adjusted for confounding factors. Aims To evaluate characteristics associated with hepatitis C virus infection in individuals infected with the HIV. Patients Cases were patients co-infected by HIV and hepatitis C virus, and controls were infected only by HIV. Methods Cases and controls were consecutively enrolled at a public health care outpatient HIV–AIDS reference centre in Porto Alegre, Southern Brazil. Results A total of 227 cases (63% men; 40.3 ± 8.7 years) and 370 controls (44.6% men; 38.9 ± 9.8 years) were enrolled in the study. In a multiple logistic regression model, male gender (odds ratio 1.9; 95% confidence interval 1.3–2.7), age between 30 and 49 years (odds ratio 2.1; 95% confidence interval 1.2–3.7), elementary school education (odds ratio 4.2; 95% confidence interval 1.9–9.6), lower family income (odds ratio 1.7; 95% confidence interval 1.1–2.7), sharing personal hygiene objects (odds ratio 2.0; 95% confidence interval 1.3–3.3), using injected drugs (odds ratio 21.6; 95% confidence interval 10.8–43.0) and crack cocaine (odds ratio 2.8; 95% confidence interval 1.1–6.9) were independently associated with co-infection by hepatitis C virus. Conclusion These results confirm the risk profile for hepatitis C virus–HIV infection and suggest that sharing personal hygiene objects might explain the transmission of virus C to those not infected by the usual routes, which may be of relevance for developing preventive strategies.
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