Treatment of interferon non-responsive chronic hepatitis C with triple therapy with interferon, ribavirin, and amantidine can be encouraging.

Patients with hepatitis C virus infection who do not respond to treatment with interferon alone or its combination with ribavirin present a serious clinical challenge and there is no clear choice for treatment in these individuals.1,2 Earlier studies with antiviral amantidine, which has been used in influenza, had shown promising …