A preclinical evaluation of the antianginal activity of energy metabolism intermediates

: In acute experiments on dogs and cats with occlusion of the coronary arteries the antianginal activities of malate (100 mg/kg) and NAD (0.2 mg/kg) were studied. The drugs were found to increase the collateral blood flow and the contractile activity of the myocardium against the background of a moderate rise of the heart oxygen consumption and to normalize the systemic hemodynamics parameters.