Prognostic Significance of Extracellular Matrix Metalloproteinase Inducer and Matrix Metalloproteinase 2 in Epithelial Ovarian Cancer

Aims: We investigated the prognostic significance of extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase 2 (MMP-2) in epithelial ovarian cancer as well as their relation to hyaluronan (HA) expression. Methods: The expression of EMMPRIN and MMP-2 was analyzed immunohistochemically in 295 primary epithelial ovarian cancer patients and 67 metastases. Results: A low membranous EMMPRIN expression was detected more often in serous tumors than in other types (p Conclusion: Our results show that EMMPRIN and MMP-2 in cancer cells are significant indicators of a favorable prognosis of epithelial ovarian cancer.