Иммунные нарушения и их фармакологическая коррекция при хроническом гингивите у подростков

The aim of the study was to assess the level of cytokines and components of the complement system in blood plasma and in gingival pocket wipe-sample in teenagers with chronic generalized catarrhal gingivitis against the background of the use of Parodontocide gel. 42 teenagers aged from 14 to 17 years with chronic generalized catarrhal gingivitis were under constant observation. They were divided into 2 groups: patients of the 1st group received basic treatment, and patients of the 2 groups additionally received Parodontocide gel as a part of the basic therapy. Before therapy and after 2 weeks, the levels of tumor necrosis factor alpha (TNFα), IL-2, IL-1α, IL-6, IL-8, interferon α (IFα), IL-18, IL-4, and IL-10, interleukin-1 receptor antagonist (IL-1Ra), C 3 -, C 3 - C 4 -, C 5 -, C 5a -components of complement, H factor, C 1 -inhibitor and sIgA were determined. The use of basic therapy only in teenagers with chronic generalized catarrhal gingivitis does not have an adequate immunocorrective effect on the cytokine level and the complement system, but requires the use of additional pharmacological correction, the gel-like drug «Parodontocid» is effective in this regard.