Vitamins C and E attenuate lipid dystrophy in tissues of rats administered aluminium

To investigate the effects of aluminum chloride (AlCl 3 ) in the deviation of tissue lipid profiles and ways to reduce its effect using antioxidant vitamins C and E, thirty-six male albino rats (120-150g) were divided into six groups with six rats each. Group (1) received normal saline and served as control, Group (2) was administered with AlCl 3 (20mg/kg body weight b.wt)), Group (3) was administered with vitamin C (200mg/kg b.wt), Group (4) was administered with vitamin E (200mg/kg b.wt), Groups (5) and (6) were administered aluminium (20mg/kg b.wt) along with vitamins C and E (200mg/kg b.wt) respectively. At the end of the experiment, blood samples and organs (liver, testis, heart, kidney and brain) were harvested and used for lipid profile determination. The results showed that oral administration of aluminum significantly (p 0.05) in rats supplemented with vitamin C and vitamin E compared with control. The vitamins significantly attenuated the affected lipid levels in the tissues affected. It was concluded that administration of vitamin C and vitamin E supplements may be used as therapies against the effects of Aluminium exposure on lipids. Keywords: Aluminium exposure, lipid dystrophy, vitamin C, vitamin E, tissues