HCC : PE-070 ; The comparison of overall survival between Child C early stage HCC and Child A advanced stage HCC

Background/Aim: The prognosis of hepatocellular carcinoma (HCC) is affected by stage as well as liver function. We analyzed the outcome of early stage HCC in Child-Pugh class C patients and advanced HCC in Child-Pugh class A patients. Methods: Among 453 HCC patients, group I included consecutive 33 patients with early stage (I,II) in Child-Pugh class C and Group II included 45 consecutive patients with advanced stage (III, IV) in Child-Pugh class A. We compared clinical characteristics, complications of cirrhosis, overall survival between two groups. Results: Younger age, male, presence of HBV, α-fetoprotein (AFP) (>400ng/ml), and MELD score (<15) were significantly high in advanced stage HCC in Child-Pugh class A patients (Group II) (p<0.05). Complications of cirrhosis such as variceal hemorrhage, ascites, and hepatic encephalopathy were increased in the Group I (p<0.05). Median overall survival was 24.5 months (95% CI 10.6-38.4) for Group I and 13.5 months (95% CI 4.6-22.3) for Group II (p=0.281). AFP was an independent prognostic factor in early stage in Child-Pugh class C patients (Group I). MELD score and tumor stage were independent prognostic factors in advanced stage in Child-Pugh class A patients (Group II). Conclusion: Overall survival was not different between two groups. AFP was a prognostic factor in early stage in Child-Pugh class C patients (Group I), whereas MELD score and tumor stage were prognostic factors in advanced stage in Child-Pugh class A patients (Group II).