Selective Intra-Arterial Embolization for Advanced Extrascleral Uveal Melanoma

Purpose: To report a treatment approach for advanced extrascleral uveal melanoma. Methods: We performed clinical examination including magnetic resonance imaging, computed tomography, angiography, and histopathologic analysis. Case: A 49-year-old healthy woman presented with a 7-year history of an enlarging pigmented mass in her right orbit. Malignant melanoma was diagnosed after biopsy with immunohistochemical stains. Treatment included selective intra-arterial embolization. Results: A significant reduction in tumor burden was seen 3 months after intra-arterial embolization. No complications were associated with the treatment. Conclusion: Selective intra-arterial embolization may allow adequate palliative therapy in select cases of advanced extrascleral uveal melanoma.