Study of the Antiinflammatory Effect of Total Flavonoids from Senecio scandens Buch-Ham

Objective To investigate the anti-inflammatory effect of the total flavonoids in Senecio scandens Buch-Ham.Methods Various inflammatory models,including the swelling of ear induced by xylene in mice,the permeability increase of blood capillary by acetic acid in mice,and the cotton-pellet granuloma of the mice were used to explore the anti-inflammation of the total flavonoids.Air sac models of synovitis in mice were set up and the amount of white blood cell(WBC)and the content of prostaglandin E2(PGE2) were measured in inflammatory exudan.Results The total flavonoids had significant inhibitory action on auris swell induced by xylene in mice and penetration of capillary vessel in mice.The general flavonoids also decreased the proliferation of granuloma caused by implantation cotton pellet in mice significantly.The amount of WBC and content of PGE2 in the experimental groups were obviously lower than those in the control groups.Conclusion The total flavonoids has significant anti-inflammation,which is relevant to the inhibition of the production and release of the inflammatory factor PGE2.