Method for restraining infiltration and metastasis of breast cancer cells by using target CCL 18 and application thereof

The invention provides a method for restraining infiltration and metastasis of breast cancer cells by using a target promoting tumour progression factor CCL 18, which is characterized by restraining the action of the CCL18 from tumour related macrophage in a target mode, and specifically, a neutralization antibody of a CCL8 or the siRNA of silent CCL18 mRNA is utilized to restrain the action of the CCL 18. The invention also provides a medicament for restraining the infiltration and metastasis of breast cancer cells, which contains components restraining the action of the CCL 18, comprising the neutralization antibody of the target CCL 18 or the siRNA of the CCL18 mRNA. The invention ensures that the treatment of CCL 18 secreted by a target TAM has general application value and overcomes the selectivity of Drug therapy to cases of breast cancer. The invention provides the method taking the CCL 18 as a target spot, makes up the defects of operation, radiotherapy, chemotherapy and endocrine therapy, and enlarges the range of target therapy.