The effects of blood pressure control levels on the renoprotection of type 2 diabetic patients without overt proteinuria

Abstract Background There is little evidence regarding the target blood pressure level in patients with type 2 diabetes mellitus without overt proteinuria. Methods and Results We followed 608 Japanese patients with type 2 diabetes without apparent cardiovascular disease and overt proteinuria who underwent cerebral magnetic resonance imaging for a mean of 7.5 years. The patients were categorized according to their mean systolic blood pressure during the follow-up period (strict: Conclusions In nonproteinuric diabetic patients without SCI, strict blood pressure control was associated with improved renal outcomes. There may be different effects of intensive blood pressure control on the renoprotection of diabetic patients according to their complications.