The effects of inhomogeneities on MCG due to a single current dipole

The aim of this study was to quantify the effects of inhomogeneities on magnetocardiography (MCG) forward solutions. A numerical model of a human torso was used which construction included geometry for major anatomical structures such as subcutaneous fat, skeletal muscle, lungs, major arteries and veins, and the bones. Simulations were done with a single current dipole placed at different sites of heart. The boundary element method (BEM) was utilized for numerical treatment of magnetic field calculations. Comparisons of the effects of different conductivity on MCG forward solution followed one of two basic schemes: 1) consider the difference between the magnetic fields of the homogeneous torso model and the same model with one inhomogeneity of a single organ or tissue added; 2) consider the difference between the magnetic fields of the full inhomogeneous model and the same model with one inhomogeneity of individual organ or tissue removed. The results of this study suggested that accurate representation of tissue inhomogeneity has a significant effect on the accuracy of the MCG forward solution. Generally lungs, subcutaneous fat, skeletal muscle play a larger role than other tissues. Our results showed that the inclusion of the boundaries also had effects on the topology of the magnetic fields and on the MCG inverse solution accuracy.