The effect of radiation exposure on multidrug resistance: in vitro and in vivo studies using non-small lung cancer cells

Background Technetium-99m methoxyisobutylisonitrile (Tc MIBI) is a substrate with the same uptake kinetics as doxorubicin. Multidrug resistance (MDR) is a mechanism that impedes chemotherapy of non-small cell lung cancer (NSCLC). We examined the effect of radiation exposure on MDR in NSCLC and the synergy between an MDR modulator, GG918, and radiation, using 99mTc MIBI in vitro and doxorubicin in vivo.