Solution and solid phase synthesis of pteridines, purides and related compounds

This paper describes the solution and solid phase synthesis of different heterocyclic systems from the common intermediate 6 and 16. A series of pteridines, purines and a 7-deazaguanine have been synthesized in solution. The chemistry has been transferred to the solid phase using a polystyrene resin through a sulfur linker. Cleavage of the resins has been achieved by oxidation followed by nucleophilic displacement.