LAÇASSE CATALYZED-SYNTHESIS OF 4,4'-BIPHENYLDIAMINE FROM P-CHLOROANILINE. EVALUATION OF ANTIFUNGAL AND ANTIOXIDANT ACTIVITIES

Laccase is a copper-containing oxidase that catalyzes reduction of molecular oxygen to water and the oxidation of a phenolic compound. In this paper, laccase was utilized to synthesize 4,4’-Biphenyldiamine using p -chloroaniline as substrate by means of a coupling reaction. The synthesized compound, 4,4’-Biphenyldiamine, presented low antifungal activity against the phytopathogenic fungus Botrytis cinerea , however the antioxidant ability, measurement by ORAC-PGR method, was higher than substrate. This work corresponds to the first report of synthesis 4,4’-Biphenyldiamine, from p -chloroaniline in a lacasse-catalyzed reaction.