Highly selective bile acid hydroxylation by the multifunctional bacterial P450 monooxygenase CYP107D1 (OleP)

Sascha Grobe,Agata Wszolek,Henrike Brundiek,Melinda Fekete,Uwe T. Bornscheuer

Highly selective bile acid hydroxylation by the multifunctional bacterial P450 monooxygenase CYP107D1 (OleP)

2020

Sascha Grobe
Agata Wszolek
Henrike Brundiek
Melinda Fekete
Uwe T. Bornscheuer

Objective Regio- and stereoselective hydroxylation of lithocholic acid (LCA) using CYP107D1 (OleP), a cytochrome P450 monooxygenase from the oleandomycin synthesis pathway of Streptomyces antibioticus.

Keywords:

Oleandomycin
Streptomyces antibioticus
Cytochrome P450
Bile acid
Biochemistry
Lithocholic acid
Hydroxylation
Biology
Monooxygenase
Stereoselectivity
p450 monooxygenase

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