Study on the Seasonal Changes of Monoamine Neurotransmitter in Hypothalamus to Probe into the Mechanism of the Kidney Responding to Winter

Objective: To probe into the mechanism of kidney responding to winter(seasonal changes in reproduction) by investigating the seasonal changes of monoamine neurotransmitter and their metabolites in golden hamster hypothalamus Methods: To measure norepinephrine(NE),dopamine(DA),5-hydroxytryptamine(5HT),5-hydroxy-3-indoleacetic acid(5-HIAA),homovanillic acid(HVA) in golden hamster hypothalamus gotten on Spring Equinox,Summer Solstice,Autumnal Equinox and Winter Solstice by high performance liquid chromatography with electrochemical detector.Results:The level of NE was lower in winter and spring than in summer and autumn,and showed the same tendency with the seasonal changes of reproduction.The level of 5-HT and 5-HIAA was higher in winter and spring than in summer and autumn,which showed a contrary tendency with the seasonal changes of reproduction.Conclusion:It is possible that NE in hypothalamus adjusts or controls the seasonal changes of reproduction,and 5-HT plays inhibiting action in seasonal changes of reproduction.