The effects of the SLCO2B1 c.1457C > T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.

ObjectiveThe objective was to determine the effects of the SLCO2B1 c.1457C>T polymorphism and apple juice on the pharmacokinetics of fexofenadine and midazolam in humans.MethodsIndividuals were divided based on the genotype of SLCO2B1 c.1457C>T (n=14, c.[1457C]+c.[=] 5, c.[1457C]+c.[1457C>T] 5, and