Level and significance of plasma homocysteine in elderly coronary heart disease patients with osteoporosis

Objective To investigate the relationship between plasma homocysteine (Hcy) and elderly coronary heart disease patients with osteoporoisis.Methods Ninety-eight elderly patients with coronary heart disease were divided into three groups according to the average T value of bone mineral density(BMD):patients in group A(29 cases) were osteoporosis group,patients in group B(37 cases)were osteopenia group,and patients in group C(32 cases) were normal group.Twenty-five healthy cases as normal control group(group D).SBP,DBP,TG,LDL-C,HDL-C,TC,BMI,Hcy,blood calcium,blood phosphorus and hs-CRP levels were compared among the four groups.Results Levels of plasma Hcy in group A and group B were higher than those in group C and group D,and that in group A was higher than that group B,in group C was higher than that in group D (P ＜ 0.05).BMD was negatively correlated with plasma Hcy(r =-0.581,P ＜0.05).BMI and osteoporosis were the risk factors that affected Hcy(b1 =-0.68,b2 =3.459,P ＜ 0.05).Conclusions Elevated plasma Hcy levels in elderly coronary heart disease patients with osteoporosis may be correlated with the decrease of BMD.Hcy level may be independent risk factor for osteoporosis in coronary heart disease patients. Key words: Homocysteine ;  Coronary heart disease ;  Osteoporosis;  Elderly;  Bone mineral density