Chemical modifications to alter monoamine releasing activity of phenmetrazine analogs as potential treatments of stimulant addiction

and gender, a multiple regression analysis revealed that ACOA status significantly predicted alcohol-related problems (p< .01, R2 = .425). Further, ACOA status moderated the effect between affect lability and problems, B=626, p< .01. Conclusions: Higher affect lability predicted more alcoholrelated problems and this effect was strengthened for those classified as an ACOA, making them more vulnerable to alcoholrelated problems. These results have practical implications on the prevention of risky alcohol use among young adults. Further research is needed to determine the causal mechanisms involved. Financial support: This work was supported by a fellowship from the Society of Public Health Education.