Atividade cicatrizante e estudo toxicológico pré-clínico do fitoterápico sanativo®

SUMMARY. “Healing Activity and Pre-Clinical Toxicological Study of Phytotherapic Sanativo®”. The wound healing activity of phytotherapic Sanativo®(SAN) and the possible hazard effects of the subchronic administration of SAN were evaluated in rats. SAN induced significant decrease in the area of the open wound in the rat dorsum. In the sub-chronic toxicity studies, SAN in doses of 1,675 g/kg, decreased the gain in body mass, but this was significant only in the first week of administration. SAN produced only a few significant alterations in the hematological and biochemical parameters, although without dose-response correlation and were within the parameters of this species. The histological analysis of the tissues did not show changes. In conclusion, Sanativo® possesses significant healing property in the open wound model and low toxicity in Wistar rats.