Precise subcellular functional organization of excitation and inhibition in the direction-selective ganglion cell circuit

Recent studies indicate that the precise timing and location of inhibition (I) and excitation (E) on the dendritic tree can significantly impact neuronal function. However, the spatiotemporal scale over which synaptic inputs are coordinated and integrated in intact circuits remains unclear. Here, analysis of isolated local light-evoked Ca2+ signals in the dendrites of retinal direction-selective ganglion cells reveals that synaptic inputs are integrated within semi-independent micron-scale subunits (