A method for preparing 3-amino-2-chloro-acrolein intermediate etoricoxib

The present invention discloses a method for preparing 3-amino-relying acrolein valdecoxib chloro intermediate. The method is based on acid as a starting material bran, bran acid is reacted with p-toluidine to afford Intermediate 7; Intermediate 7 to give intermediate 8 was hydrolyzed in an organic acid, a reaction intermediate 8 in aqueous ammonia to give 3 - amino-2-chloro-acrolein. P-toluidine as a solid, low toxicity, nucleophilic stronger than aniline, the present invention is employed in a high yield; the present invention simplifies the procedure and reduces the production cost, industrially more advantageous reaction; after treatment of the invention process easier, improving the cleaning efficiency on the basis, further reducing the complexity of the process operation.