Scalable Electrochemical Dehydrogenative Lactonization of C(sp2/sp3)–H Bonds

A practical, electrochemical method is developed for the direct dehydrogenative lactonization of C(sp2/sp3)–H bonds under external oxidant- and metal-free conditions, delivering diverse lactones, including coumarin derivatives with excellent regioselectivity. The scalable nature of this newly developed electrochemical process was demonstrated on a 40 g scale following an operationally simple protocol. The remote lactonization of C(sp3)–H bonds would constitute an important synthetic advance toward electrochemical C–O bond formation.