Nickel-Catalyzed, para-Selective, Radical-Based Alkylation of Aromatic Ketones
2020
A direct, para-selective, radical-based alkylation of aromatic ketones with alkanes has been developed using a nickel catalyst with oxamide as the ligand. Acetophenones bearing electron-withdrawing substituents were functionalized directly with simple alkanes with high para-selectivity while acetophenones with electron-donating groups were mainly para-functionalized. A mechanistic study indicated that C–H bond activation of the aromatic ring may be the rate-determining step of the reaction.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
26
References
2
Citations
NaN
KQI