Method for preparing roflumilast tablets
2015
The invention provides a method for preparing roflumilast tablets. The method includes steps of a, weighing raw materials and excipients including, by weight, 1 part of roflumilast, 20-450 parts of lactose, 10-250 parts of corn starch, 3-25 parts of povidone K90 and 0.5-25 parts of magnesium stearate; b, dissolving the roflumilast and the povidone K90 in 50-95% ethyl alcohol to prepare medicine-containing adhesive; c, sieving the lactose and the corn starch and mixing the lactose and the corn starch with each other to obtain mixtures; d, adding the medicine-containing adhesive obtained at the step b into the mixtures of the lactose and the corn starch and carrying out granulation, drying, shaping, total blending and tabletting to obtain the tablets. The method for preparing the roflumilast tablets has the advantages that the medicine content uniformity can be guaranteed, raw material micronization for controlling the particle sizes can be omitted, and dissolution of indissolvable medicines can be improved; the indissolvable medicines can be jointly dissolved, accordingly, technological operation steps can be reduced, energy can be saved, and the cost can be lowered.
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