Local using prostaglandin micro emulsion and its preparation method

The present invention discloses a locally applied prostaglandin micro-emulsion and the preparation method thereof, the present invention is a liquid or semi-solid preparation which is composed of prostaglandin E1 or the derivatives and the pharmaceutical acceptable excipients, the present invention is characterized in that the present invention contains the prostaglandin E1 or the derivatives, oil phase, emulsifiers, assistant emulsifiers and water, which may also contain the osmotic promoting agents, thickeners and preparation stabilizers; the present invention is characterized by transparent or translucent solution, stable thermodynamics, simple preparation process and so on. The micro-emulsion prepared by the present invention has good transdermal permeability and provides a safe and effective new preparation for the clinical medication of the prostaglandin E1 or the derivatives. The present invention can treat the erectile dysfunction by urethral administration and can treat the ulcers on the four limbs caused by chronic arterial occlusive disease, the resting pains on the four limbs caused by microcirculation disorder and other diseases by external application.