Studies on Peptides. LXXVII. Synthesis of the Protected Heptadecapeptide corresponding to Positions 13-29 of Avian Glucagon (Duck)

As a starting material for the total synthesis of duck glucagon, the C-terminal protected heptadecapeptide, Boc-Tyr-Leu-Asp (OBzl)-Thr-Arg (MBS)-Arg (MBS)-Ala-Gln-Asp-(OBzl)-Phe-Val-Gln-Trp-Leu-Met (O)-Ser-Thr-OH (position 13-29), was synthesized by successive azide condensation of 4 peptide fragments ; (position 13-14), (15-19), (20-23) and (24-29).