Biomolecular basis of the role of chronic psychological stress in the susceptibility of HIV infection and progression of AIDS

people without CPS. T-cells have CXCR4 receptor and Macrophages have CCR5 receptor which can bind with both glucocorticoid and catecholamine hormone. HIV has GP120 residue which is able to bind with both CD4 and CXCR4/CCR5 receptor for its entry into the host cells. CPS increases glucocorticoid and catecholamine concentration in blood and thereby activates cAMP signaling pathway through binding the CXCR4/CCR5 receptors expressed on T cells and macrophages. This signal transduction pathway leads to the synthesis of more CXCR4 and CCR5 receptors by those cells, and in turn the cells become more susceptible to HIV infection. On HIV