Novel Approach for Synthesis of (.+-.)-Calanolide A and Its Anti-HIV Activity.
1995
Abstract Anti-HIV agent (±)-calanolide A ( 1 ) has been synthesized. The key intermediate, chromene 5 , was synthesized by the sequence of Pechmann reaction, acylation and chromenylation by 4,4-dimethoxy-2-methylbutan-2-ol. The anti-HIV activity for synthetic (±)- 1 has been determined and compared with the natural product.
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