AN IMMUNOLOGICAL OBSERVATION ON RECOMBINANT HEPATITIS B SURFACE ANTIGEN (RHBSAG) AS A PROTEIN IMMUNOMODULATOR TO CONJUGATE IT WITH VI CAPSULAR POLYSACCHARIDE OF SALMONELLA TYPHI

Typhoid fever is a systematic disease caused by salmonella enterica serotype typhi. This pathogen is exclusive to human being and right now is the most common in developing countries. In recent years multi-resistant salmonella enterica serotype typhi were reported from around the world. The prevalence of these types especially in developing countries increased the mortality rate. Recent prevalence of typhoid fever with multi-resistant antibiotic in Indian subcontinent, Far East and Latin America is the obvious reason. It seems that salmonellas is control can be done solely with general vaccination. The present study aims at covalent binding of Vi polysaccharide of Salmonella typhi to the surface protein of hepatitis B virus in order to add to the immunity caused by Vi polysaccharide. Also, it investigates the level of stimulation of anti Vi IgM, Ig ��, Ig ��� , Ig ��� , Ig ��, and total IgG, antibodies by conjugated ��-HbsAG and ��.