HEMATOLOGICAL EFFECTS OF DICLOFEN AC SODIUM IN GOAT

-1 diclofenac was administered in all animals with 2.5 mg/kg body weightandin phase-2with1 mg/kgdose rate.Bloodparameters altered significantly o nly with the high dose (2.5 mg/kg) of diclofenac sodium. red blood cells was significant decrease (P<0.05) at 12 hoursand hemoglobin (at 6 and 12 hours) was observed with the high dose of the drug. A significant increased P<0.05) was detected in WBCs count at 6, 12 and 24 hours post high dose of diclofenac. Granulocytes decreased significantly (P<0.05) at 6 and 12 hours post high dose administration. Monocytes and lymphocytes increased significantly (P<0.05) with high dose of diclofenac at 6,12,24,48 and a t 12 and 24 hours respectively. Decreased (P<0.05) platelets count was marked at 12 and 24 hours post diclofenac administration. It has been concluded that high dose of diclo fenac sodium significantly affect bloodcell count andthe effects are drug relate d andsubside72 hourspost drug administration.