β-Lactolin, a Whey-Derived Gly-Thr-Trp-Tyr Lactopeptide, Promotes Cerebral Blood Flow During Cognitive Tasks: A Randomized Controlled Trial

Objectives Due to the rapid aging of society, the prevention of age-related cognitive decline and dementia has gained increasing attention. Recent epidemiological investigations have shown that the consumption of dairy products reduces the risk of dementia in older adults. β-lactolin, a whey-derived Gly-Thr-Trp-Tyr lactopeptide, activates the dopaminergic system, improves memory impairment, and prevents Alzheimer's pathologies in a rodent model. We have demonstrated that β-lactolin supplementation improves memory retrieval and selective attention in randomized trials. On the other hand, the mechanisms underlying the effects of β-lactolin on human brain activity have not been investigated.