Reductive cleavage of the ribose moiety in purine nucleosides using diisobutylaluminum hydride: A new method for the preparation of acyclonucleosides

Abstract Reaction of purine nucleosides, such as 2′,3′- O - isopropylideneinosine 1a and 2′,3′- O -isopropylideneadenosine 1c , with diisobutylaluminum hydride in dry tetrahydrofuran resulted in the reductive cleavage of the ribose moiety at the anomeric position to give the corresponding 9-(2′,3′- O -isopropylideneribityl)purines 2a , c in good yields.