Prognostic significance of cyclin E overexpression in laryngeal squamous cell carcinomas.
2000
Cyclin
E plays a pivotal role in the regulation of G 1 -S transition
and relates to malignant transformation of cells. However, the clinical
significance of cyclin E in patients with laryngeal squamous cell
carcinoma (LSCC) remains unknown. We examined the expression of cyclin
E in 102 patients with LSCC and analyzed its relation to
clinicopathological parameters, cell proliferation, and clinical
outcome. Cyclin E overexpression was observed in 54 cases (52.94%) of
LSCC and was significantly correlated with the tumor site
( P = 0.012), tumor size ( P =
0.006), poor differentiation ( P = 0.026), lymph
node metastasis ( P = 0.012), and advanced stage
( P = 0.002). A positive correlation between the
cyclin E expression and proliferative activity of tumor cells was found
( r = 0.896; P < 0.0001).
Kaplan-Meier analysis showed that shorter disease-free and overall
survival was significantly associated with proliferating cell nuclear
antigen (PCNA) overexpression and cyclin E overexpression. When PCNA
and cyclin E are combined, the patients with both PCNA overexpression
and cyclin E overexpression had the poorest prognoses when compared
with the other cases. Additionally, in early stage (I–II) cases,
cyclin E was also revealed to possess a significant prognostic role. By
multivariate analysis, lymph node metastasis and cyclin E
overexpression were independent prognostic factors for
disease-free survival, and tumor size, lymph node metastasis, advanced
stage, as well as cyclin E overexpression were independent prognostic
factors for overall survival. These findings indicate that cyclin E
overexpression is associated with unfavorable clinicopathological
parameters and represents an independent marker for cell proliferation
and prognosis of LSCC.
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