Abnormal elevation of thyroid antibody in the population without nervous system disease

Objective　To explore the rationality of Hashimoto encephalopathy (HE) as an independent disease by investigating the distribution and elevation status of thyroid globulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in the population without nervous system disease. Methods　To analyze the data of serum levels of TGAb and TPOAb in the people with normal thyroid function and without nervous system disease collected in the Medical Examination Center, Outpatient Department and Inpatient Department of Leshan People's Hospital from April 2016 to May 2017. Results　A total of 2971 people, 922 males and 2049 females, were included in present study, and 25.2% of them were with abnormal elevation of thyroid antibodies. Among the 2971 people, 511(17.2%) were with elevated TGAb and 610(20.5%) with elevated TPOAb. The percentage of individuals with more than 8 times elevation (480U/ml and above) of corresponding thyroid antibody was 21.7% in elevated TGAb people and 58.2% in elevated TPOAb people. The proportions of individuals with total elevated thyroid antibody, or with elevated TGAb or elevated TPOAb, or with elevated both TGAb and TPOAb, were obviously higher in female than in male ones (P<0.001). Conclusion　The status of elevated TGAb or/and TPOAb occupies a high proportion in people without nervous system disease, therefore cannot act as a specific diagnostic indicator of HE which might be a non-independent brain disease associated with elevated anti thyroid antibodies. DOI: 10.11855/j.issn.0577-7402.2018.07.12