Total synthesis and X-ray crystal structure of 13,14-didehydro-11-deoxy-11-methyl-l5-oxoprostaglandin E1

A new 11-methylated prostaglandin analogue bearing the unusual 13,14-didehydro-15-oxo bottom side-chain has been prepared by total synthesis. Its complete structure has been established unambiguously by a single crystal X-ray analysis.