Clinical significance of human platelet antibody in the treatment of children with immune thrombocytopenia

Objective To investigate the expression of human platelet antibodies (HPA) in children with immune thrombocytopenia(ITP) at different ages and their clinical significance in the treatment of ITP. Methods Two hundred eighty-eight cases of children who were newly diagnosed as primary ITP and detected with HPA from January 2013 to December 2015 in the First Affiliated Hospital of Zhengzhou University were selected.According to the HPA values, they were divided into 1︰10 group.According to their age, they were divided into <3-year-old group and ≥ 3-year-old group.Data were organized and the relationship among platelet antibody, age, gender and short-term efficiency of treatment was analyzed by using SPSS 21.0 statistical analysis software. Results In this study, there were 288 cases of children, with male to female ratio of about 1.3︰ 1.0.As to the 0.05). Regarding the short-term efficiency, HPA in 1︰10 group was respectively 89.1%, 89.1%, 100.0%.Statistical analysis suggests︰ the short-term efficiency of 0.05); In comparison of 1︰10 group(χ2=4.268, P 1︰10 group(χ2=4.411, P<0.05), their differences were statistically significant. Conclusions This study suggests that boys are more susceptible to ITP, especially in the 1︰10 group may have higher short-term efficiency in clinical practice. Key words: Immune thrombocytopenia; Human platelet antibody; Age; Gender; Short-term efficiency of treatment