The Prognosis Of Primary Generalized Epilepsy In Patients With Parental Consanguinity: A One-Year Retrospective Study (P2.189)

Background:Studies describing the long-term prognosis of primary generalized epilepsy (PGE) are rare, yet it is believed that this epilepsy class is associated with favorable prognosis. Data on the influence of parental consanguinity (PC) on the prognosis of PGE are scant for which this study aimed to evaluate. Methods:Patients with PGE registered in our epilepsy registry between January 2012 and June 2013 were identified, and those with a one year follow up were only included. Epilepsy risk factors were determined for all patients, as well as the presence of family history of epilepsy (FHE) and PC. Seizure control was recorded at 6 and 12 months follow up, but predictors of seizure control were assessed at 12 months. Results: 84 patients were studied. There were 47 men (56%), mean age at epilepsy onset was 14.6 years. FHE was documented in 23 patients (27.4%), and PC (first and second degrees) was observed in 22 patients (26.2%). At 12 months, seizure freedom was documented in 71 patients (84.5%). 23% of patients who continued to have seizure at 12 months had first degree PC, which was only documented in 2.8% of patients who were seizure free during the same period (p value = 0.025). Second degree PC and FHE were seen in no particular distribution across the two groups. Multiple regression analysis showed that first degree PC was 17 times more likely to be associated with unfavorable prognosis in one year follow up of patients with PGE (odds ratio =17.7, p values = 0.027, 95% CI = 1.4-22.6). Other factors such as gender, age at epilepsy onset, FHE and other PC could not predict prognosis in one year. Conclusions: The presence of first degree PC was associated with unfavorable prognosis in patients with PGE. This observation may indicate a genetic influence of PC on idiopathic epilepsy, but larger studies are recommended to support such an observation. Disclosure: Dr. Assiri has nothing to disclose. Dr. Babtain has nothing to disclose. Dr. Babtain has nothing to disclose. Dr. Velmurugan has nothing to disclose.