Synthesis and in Vitro Cell Compatibility of α-Tricalcium Phosphate-Based Apatite Cement Containing Tricalcium Silicate

The presence of silicate in artificial bone graft material is known to be effective in increasing bone formation rate. We previously reported the basic setting properties of α-tricalcium phosphate (α-Ca3PO4; α-TCP) based apatite cement (AC) with various amount of tricalcium silicate (Ca3SiO5; alite) addition using sodium dihydrogen phosphate (NaH2PO4) as the liquid phase. In this study, in vitro biological compatibility of pure α-TCP and 2.5-10.0 wt% alite added to α-TCP based AC is investigated in terms of cell attachment, proliferation and differentiation.