Intravesical Prostaglandin F2 for Promoting Bladder Emptying after Surgery for Female Stress Incontinence

Summary— Prostaglandin F2α 10 mg was administered intravesically in a double-blind placebo-controlled study to promote micturition in cases of urinary retention after operative treatment of urinary stress incontinence in women. Fifteen of 18 patients (83%) succeeded in voiding after treatment with prostaglandin F2α, but the placebo was ineffective in all 18 patients (P<0.001). Although the effect of prostaglandin F2α on bladder muscle contraction was short-lived, it seemed to enhance the restoration of bladder motor function with no serious side effects, and thus to be clinically useful in the treatment of post-operative urinary retention.