Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors.
2010
Abstract The synthesis and structure–activity relationships (SAR) of novel, potent imidazo[1,2- a ]pyrazine-based Aurora kinase inhibitors are described. The X-ray crystal structure of imidazo[1,2- a ]pyrazine Aurora inhibitor 1j is disclosed. Compound 10i was identified as lead compound with a promising overall profile.
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