Changes in circulating levels of carboxymethyl-lysine, soluble receptor for advanced glycation end products (sRAGE) and inflammation markers in women during normal pregnancy

Abstract Objective: Determine circulating levels of insulin, carboxymethyl-lysine (CML) (Ne- carboxymethyl lysine), soluble RAGE (sRAGE) (soluble receptor for advanced glycation end products), and markers of inflammation and oxidative stress in maternal and umbilical cord blood in a cohort of healthy women with normal pregnancy. Methods: We conducted an observational longitudinal study in a group of women (n = 31; age range 18–39 yrs) with healthy pregnancy starting at 30 weeks of gestation and finishing at the time of delivery. We collected weight and height in the participants and their neonates and calculated BMI. Blood from each patient was collected at week 30th of pregnancy and at delivery when a sample of cord blood was also obtained. Glucose, lipid profile, Ne- carboxymethyl lysine, sRAGE, malondialdehyde (MDA), tumor necrosis factor- α (TNF-α), highly sensitivity C-reactive protein (hsPCR), and insulin were determined. The study was approved by the University of Guanajuato Institutional Ethics Co...