A double-masked, randomized, placebo-controlled trial of temporary endoscopic mucosal gastric electrical stimulation for gastroparesis

Results: In session 1, vomiting decreased in both groups, but was greater with stimulation, resulting in a day 3 difference of 1.02 (95% CI, 1.62 to 0.42; P .001). Scores did not return to baseline during washout; on day 4, the difference persisted at 1.08 (95% CI, 1.81 to 0.35; P .005). In session 2, vomiting slightly decreased with stimulation and slightly increased without it; at day 8, the nonactivated group had nonsignificantly greater vomiting, 0.12 ( 0.68 to 0.92; P .762). An overall treatment effect of a slight, nonsignificant daily decrease in average vomiting scores, 0.12 ( 0.26 to 0.03; P .116), was observed by pooling stimulation effects across sessions.