Assessment of nutrition and muscle mass loss in patients with severe COPD.

Aim: To assess the nutrition and muscle mass loss in patients with severe COPD and its phenotypes. Methods: We analysed baseline data of patients with severe COPD from the Czech Multicenter Research Database. We assessed BMI (Body Mass Index), FFMI (Fat Free Mass Index) measured by Skinfold Anthropometry and MAMC (Mid-arm muscle circumference) in non-dominant upper arm. Results: A total of 337 patients were included in the analysis, 248 men, mean age 66.7 years, mean FEV1 44.9%, average CAT 16.8. There were 10.1% patients with cachexia, 5.1% with underweight, 31.2 % patients were obese. Total of 79.5% patients had normal muscle mass, 20.5% had muscle mass loss. Emphysematic phenotype was associated with cachexia (p=0.02), underweight and muscle mass loss (p=0.002), obesity was less common in emphysematic phenotype (p Conclusion: Poor nutrition status and non-physiological muscle mass loss are associated with certain COPD phenotypes, with worse lung function and with higher frequency of symptoms and exacerbations. Prospective follow-up and prognostic evaluation of nutritional status will continue.