Altered expression of microRNA-30a-3p in papillary thyroid cancer and its association with clinicopathological characteristics
2019
A growing number of studies suggest a tumor suppressive role and potential
prognostic significance of miR-30a-3p in different types of cancer. However,
relatively few studies have focused on this microRNA in neoplastic thyroid
lesions, including papillary thyroid cancer (PTC). The aim of our study was
to shed more light on the potential involvement and clinical relevance of
miR-30a-3p in this type of cancer. We examined the expression levels of this
microRNA in 42 pairs of PTCs and matched non-tumor thyroid tissues using
quantitative RT-PCR. We analyzed their association with clinical and
histopathological parameters. The results revealed that miR-30a-3p was
significantly downregulated in the majority of PTC tissues compared to
corresponding non-tumor tissues. Moreover, decreased expression of
miR-30a-3p was associated with advanced clinical stage, presence of multiple
tumor foci and capsular invasion, suggesting a role in aggressive disease.
Although the role of this microRNA and its prognostic utility remain to be
elucidated, the presented data suggest that downregulated expression of
miR-30a-3p indicates poorer prognosis in PTC patients, warranting further
investigations. [Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. ON173049]
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